I have a friend who swears by Neosporin for curing the random painful cystic pimples that pop up deep within the skin. You know the type -- these guys are super painful and tender to the touch, a tell-tale sign that they're infected.
My friend discovered the Neosporin trick one day when she was suffering from a cystic pimple and decided to spot treat it with the ointment. She was nervous because Neosporin is rather oily and she didn't want to inflame her skin so she applied a tiny dab right over the swollen spot. It worked beautifully. The pain went away immediately and the swelling went down and within 3 days, the pimple had vanished. Usually, she reports, it takes more than a week for such pimples to disappear and there's always the risk that the skin will break and a scar could develop.I do not recommend the Neosporin treatment for people suffering from major acne, in this case you should always consult a dermatologist. Neosporin should be used only to spot treat the occasional pimple and I advise testing the skin first behind the ear or under the jaw to make sure you don't have a reaction.
Crushed aspirin is also purported to work like a miracle on pimples. See my recipe here.